A couple of my current research topics:
1) Whether I should (and if the answer is yes, then how to) rehost Graphic-Forms on the .NET Framework, thus abandoning User32/GDI?
RDNZL is proof that Common Lisp and .NET integration is possible. Dr. Weitz certainly got people's attention with that project (which as he points out was heavily inspired by earlier work on an earlier Scheme-based project). I also discovered that the SWT folks have proposed doing a port of that Java-based GUI library. So feasability does not seem to be in doubt. The question is whether it makes sense for my project.
2) What is it really like to develop non-trivial applications with XAML and WPF?
I've experimented with toy examples using Visual Studio 2005 Express plus the extra components needed for .NET 3.0, and viewed tutorials such as this one. Is this an accidental reincarnation of CLIM? It certainly has a familiar feel in some ways, especially the ability to do incremental and interactive development. I'd much prefer a sexpr-based syntax, if not a full-blown Lisp dialect. Does Guile support .NET?
Anyway, I will be devoting a big slice of my free time over the near-term to answer these questions.